drostanolone propionate

The molecular weight of the complex is so high – drostanolone propionate that its diffusion through the mucosa of the gastrointestinal tract is 40 times slower than the diffusion of the divalent iron. The complex is stable under physiological conditions and does not release iron ions. Iron cores of multi-core complex due to the similar structure of natural compounds of iron – ferritin. Because of this similarity of iron (III) complex of this active is absorbed only by suction. Iron binding proteins located on the surface of the intestinal epithelium and in the gastrointestinal fluids, absorb iron (III) complex by means of competitive exchange ligands.Absorbed iron is deposited mainly in the liver, where it binds to the ferritin. Later, the bone marrow is incorporated into hemoglobin.
Polymaltose complex iron hydroxide (III), in contrast to iron salts (II), has not prooxidant properties. Sensitivity of lipoproteins (e.g., very low density lipoproteins and low density lipoprotein) to oxidation is reduced. Studies using the method of double isotopes  have shown that iron absorption, as measured by the level of hemoglobin in red blood cells is inversely proportional to the dose ( the higher the dose, the lower the absorption). There is a statistically negative correlation between the degree of iron deficiency and the amount of absorbed iron (iron deficiency higher the better absorption). Maximum iron absorption occurs in the duodenum and jejunum. Unabsorbed iron excreted in the faeces. Its excretion exfoliating epithelial cells of the gastrointestinal tract and skin as well as sweat, bile and urine of approximately 1 mg of iron per day. In women, there is further loss of iron during menstruation, it is necessary to take into account.

Indications

• treatment of latent iron deficiency;
• the treatment of iron deficiency anemia;
• prevention of iron deficiency during pregnancy.

Contraindications

• hypersensitivity to the drug,
• iron overload of the body (eg, in cases of hemochromatosis, hemosiderosis);
• disturbance of iron utilization (eg, anemia caused by lead poisoning, sideroahrestical anemia, thalassemia);
• anemia not associated with iron deficiency (eg , hemolytic anemia, megaloblastic anemia due to vitamin B12 deficiency);
• children up to age 12 years (for a given dosage form).

 

Application of pregnancy and during breastfeeding

Before the start of the drug during drostanolone propionate pregnancy or during breast-feeding should consult a doctor.
In controlled studies in pregnant women (2nd and 3rd trimesters of pregnancy) is not marked negative impact on the mother and fetus. There were no adverse effects on the fetus when taking drugs in the first trimester of pregnancy.
Breast-feeding mother’s milk normally contains iron associated with lactoferrin. Data on the amount of iron entering the maternal milk from polymaltose complex, no. However, the occurrence of adverse effects in breastfed children is unlikely.

Dosing and Administration

Inside, the tablets can be chewed or swallowed whole. The drug is recommended to be taken during or immediately after a meal.
The daily dose can be divided into several stages.
The dosage and duration of treatment depend on the degree of iron deficiency. Latent iron deficiency duration of treatment is about 1-2 months. Children older than 12 years, adults and mothers, nursing her baby 1 chewable tablet (100 mg), per day. Iron deficiency anemia treatment duration of about 3-5 months. After normalization of hemoglobin concentration should continue taking the drug for a few more weeks to replenish iron stores in the body. Children older than 12 years, adults and mothers, breast-feeding her baby 1-3 chewable tablets (100-300 mg). pregnant womenlatent iron deficiency and iron deficiency prophylaxis 1 chewable tablet (100 mg) drostanolone propionate day. iron deficiency anemia is 2-3 chewable tablets (200-300 mg)  daily until normal hemoglobin concentration. this is followed by continue to take one tablet a day chewing, at least until the end of pregnancy to replenish the body’s iron stores.